Promethazine suppositories are for rectal use only. Never attempt to swallow the suppositories or insert in any other Element of The body.
you should know that this medication may well cause you to drowsy. Usually do not drive an automobile or run machinery right until you understand how this medication impacts you.
Ideal scientific studies haven't been performed on the relationship of age to the consequences of codeine while in the pediatric population. It should not be Employed in little ones more youthful than twelve several years of age. Basic safety and efficacy haven't been established.
To safeguard younger small children from poisoning, normally lock protection caps and right away area the medication in a secure spot – one which is up and absent and out in their sight and attain.
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To reduce your danger, your medical doctor ought to have you take the smallest dose that actually works, and consider it to the shortest probable time. See also How to Use section To learn more about dependancy.
Promethazine is metabolized via the liver to a number of inactive metabolites for example sulfoxides of promethazine, N-demethylpromethazine and also other glucuronides.
In conjunction with its essential results, a drugs might lead to some undesired consequences. Although not all these Unwanted effects may well come about, when they do take place They could want health-related consideration.
These signs may reveal that you're an "ultra-quick metabolizer of codeine". Due to this fact, There exists far too much morphine in the body and much more Unwanted effects of morphine than typical. Small children could possibly be In particular delicate to this impact. Do not give this medicine to:
Promethazine with Codeine Oral Solution is made up of codeine, a Program V controlled compound. Being an opioid, Promethazine with Codeine Oral Remedy exposes consumers for the hazards of habit, abuse, and misuse [see DRUG ABUSE AND DEPENDENCE (9)], which can lead to overdose and death [seeOVERDOSAGE (10)]. Reserve Promethazine with Codeine Oral Resolution for use in Grownup clients for whom some great benefits of cough suppression are expected to outweigh the hazards, and in whom an sufficient assessment of the etiology of the cough has been created. Evaluate Every single client's threat ahead of prescribing Promethazine with Codeine Oral Resolution, prescribe Promethazine with Codeine Oral Answer for that shortest period that is per specific affected individual treatment method objectives, watch all patients routinely for the development of habit or abuse, and refill only immediately after reevaluation of the necessity for continued procedure.
Codeine is actually a prodrug metabolized by cytochrome P450 2D6 to morphine which mediates many of the analgesic effects of codeine in your body. Around 100 variants of the enzyme (CYP2D6) result in a continuum of action.
Recommend sufferers not to increase the dose or dosing frequency of Promethazine with Codeine Oral Resolution for the reason that serious Promethazine codeine syrup adverse events like respiratory depression may well arise with overdosage.
Promethazine could lead to respiratory to slow or quit, and could induce Demise in young children. Promethazine really should not be specified to infants or youngsters who are young than two several years aged and may be provided with warning to kids that are 2 decades of age or more mature. Mix solutions that contains promethazine and codeine should not be offered to children young than sixteen years outdated. Promethazine must not routinely be employed to take care of vomiting in children; it must only be used in particular circumstances when a health care provider decides that it is desired.
Kids needs to be supervised for the duration of bicycle Using as well as other potentially dangerous things to do to stay away from damage. Restrict alcoholic beverages. Talk to your physician if you are applying marijuana (cannabis).